Digoxin ndi mankhwala omwe amagwiritsidwa ntchito kwambiri pochiza matenda a mtima, nthawi zambiri pamapiritsi. Amatchulidwa ku gulu la mankhwala la mtima wa glycosides - mankhwala a zitsamba, omwe ali ndi cardiotonic ndi antiarrhythmic effect.
Mankhwala amapangidwa ndi mankhwala opiritsa mapiritsi Digoxin
Mbali yogwira ntchito ya mankhwala Digoxidine ndi chimodzimodzi mankhwala digoxidine, otalikirana ndi masamba a chomera, digitalis woolly. Zachigawo zina za mawonekedwe a pulogalamuyi ndi awa:
- silicon dioxide colloidal;
- gelatin;
- magnesium stearate;
- talc;
- wowuma kuchokera ku chimanga;
- lactose monohydrate.
Akatengedwa pamlomo, mankhwalawa amalowa m'matumbo ndipo amatenga zotsatira zake pafupifupi maola 2-3 mutatha. Matendawa amatha kwa maola asanu ndi limodzi. Mankhwalawa amachotsedwa makamaka ndi mkodzo.
Pogwira ntchito yogwiritsira ntchito mankhwalawa, zotsatirazi zikuchitika:
- kuwonjezeka kwa mphamvu ya myocardial muscle contractions (posangalatsa kwambiri inotropic effect);
- kuwonjezeka kwa magazi oopsya;
- kuchepetseratu muzitsulo zamtundu wa minofu ya mtima;
- kuchepetsa mphamvu ya systolic ndi ya terminal diastolic ya mtima;
- kuchepetsa kutaya kwa oxygen kwa kachipatala;
- zochitika zotsutsana (pochepetsa kuchuluka kwa maganizo mwa njira ya atrioventricular ndi kupititsa nthawi yeniyeni ya refractivity);
- vasodilator kwenikweni (ndi kusokonezeka kumbuyo kwa mtima kulephera );
- chowoneka bwino;
- kutsika mpweya wochepa;
- kuchepa mu edema, ndi zina zotero.
Zizindikiro zogwiritsira ntchito mankhwala a Digoxin
Zizindikiro zazikulu zogwiritsira ntchito mankhwala Digoxin ndi zoterezi:
- kuperewera kwa mtima kwa II, III ndi IV maphunziro (monga gawo la mankhwala ovuta);
- mtundu wamagetsi wamagetsi;
- chowombera;
- paroxysmal supraventricular tachcarcardia.
Kugwirizana ndi mlingo pogwiritsira ntchito mapiritsi Digoxin
Ponena za mankhwala onse a glycosides, mtima wa Digoxin umasankhidwa mwachangu ndi dokotala yemwe akupezekapo, kuganizira za umunthu wa thupi lake, kukula kwake ndi njira ya matenda, komanso magawo a mtima wa electrocardiogram.
Mwachitsanzo, imodzi mwa mankhwala omwe amagwiritsira ntchito mankhwalawa ndi kupanga digoxin kuchuluka kwa 0.25 mg 4-5 tsiku loyamba la mankhwala, ndipo masiku otsatira - 0.25 mg katatu patsiku. Pankhaniyi, phwando liyenera kuchitika motsogoleredwa ndi madokotala.
Pambuyo pa mankhwala oyenera (kawirikawiri pambuyo pa masiku 7 mpaka 10), mlingo wafupika, kuchepetsa mlingo wa mankhwala akuyitanitsidwa kwa nthawi yaitali. Kusankhidwa kwa jekeseni wa intravenous, monga lamulo, kumafunikila kokha ngati vutoli likulephera.
Zotsatira za Digoxin:
- chisokonezo;
- kusanza;
- zovuta;
- kusowa kudya;
- mutu;
- chizungulire;
- zovuta za kugona;
- mtima;
- magazi ochuluka;
- kuyabwa;
- urticaria;
- kufooka kwakukulu;
- kutopa, ndi zina zotero.
Zotsutsana ndi ntchito ya Digoxin:
- kuledzera ndi glycosides ya mtima;
- mphutsi yoopsa ya myocardial;
- angina wosakhazikika ;
- Matenda a Wolff-Parkinson-White;
- mchitidwe wa atrioventricular;
- bradycardia ndi mawonetseredwe ofunika kwambiri;
- matenda oopsa a mtima;
- mitral stenosis ndi ena.