Warfarin analogues

Warfarin ndi mankhwala akale kwambiri omwe amachokera ku gulu la anticoagulants , mopitirira muyeso amakhala poizoni ndipo amafuna kuyang'anitsitsa nthawi zonse zizindikiro za magazi. Pakalipano, pali mafananidwe amakono a Warfarin omwe ali ndi zotsatira zochepa, zomwe zochititsa chidwi kwambiri ndizo zomwe zingatengedwe popanda kufufuza nthawi zonse za INR (chizindikiro chosonyeza coagulability ya magazi).

Warfarin wamakono Analogues

Warfarex

Mapiritsi okhala ndi 1.3 kapena 5 mg yogwiritsira ntchito (sodium warfarin). Amagwiritsidwa ntchito pa:

• thromboembolism m'mapapo;
• zozama;
• kupweteka kwa mtima;
• ma prosthetics of valves.

Marewan

Mapiritsi okhala ndi 3 mg ya warfarin. Amagwiritsidwa ntchito pa:

• thrombosis;
• kuperewera kwa matenda komanso kupewa matendawa.
• Matenda ena a mtima, kuphatikizapo ma prosthetics;
• chithandizo ndi kupewa matenda osokoneza bongo komanso zisokonezo.

Mankhwalawa onse, ali ndi Warfarin yemweyo ndipo amasiyana ndi zomwe zili zothandizira. Kuwunika INR ndi zina zoteteza pamene mukuzigwiritsa ntchito ndizovomerezeka.

Ndi chiyani chinanso chomwe chingasinthe Warfarin?

Pano ife tikambirana za kukonzekera ndi zinthu zina zogwira ntchito ndi mtundu wa zochitika zomwe ndizo anticoagulants, choncho zingagwiritsidwe ntchito m'malo mwa Warfarin.

Pradaxa

Mankhwalawa amadziwika bwino kwambiri, ndipo amawamanga, amachititsa kuti pulogalamuyo isapangidwe. Mankhwalawa amagwiritsidwa ntchito:

• pochiza ndi kupewa thrombosis ya miyendo;
• poletsa matenda , sitiroko thromboembolism;
• kuti achepetse chiopsezo cha matendawa.

Xarelto (rivaroxaban)

Inhibitor yoyamba ya factor Xa (coagulation factor, yomwe ndi prothrombin activator). Mankhwalawa amaletsa mapangidwe atsopano a thrombin ndipo samakhudza omwe ali kale m'magazi. Anagwiritsidwa ntchito popewera:

• thromboembolism pambuyo pamatenda opaleshoni kumapazi apansi;
• kukwapulidwa ndi pulogalamu ya thromboembolism kwa odwala omwe amagwidwa ndi matenda a atrial fibrillation.

Ndi chiyani chomwe chili bwino - Pradaksa, Xarelto kapena Warfarin?

Phindu lalikulu la Pradax, monga Xarelto, ndilo kuti mankhwalawa safuna kuti INR ilamulire, ndipo, ngati atengedwa, sangawonongeke. Komabe, mankhwalawa Amagwiritsidwa ntchito pa mitundu yambiri ya matenda a mtima omwe si a valvular. Izi zikutanthauza kuti ngati pali valavu kapena ma rheumatic omwe amawonongeka pamitima ya mtima, iwo sauzidwa, mosiyana ndi Warfarin.

Posankha pakati pa Xarelto ndi Pradaksa, ndi bwino kuganizira kuti Xarelto amatengedwa kamodzi patsiku, ndipo Pradaksa ingafunike njira zingapo. Kuwonjezera apo, akukhulupilira kuti Xarelto sikumvetsa chisoni kwambiri kumakhudza matumbo a m'mimba.

Popeza mankhwalawa amakhudza zizindikiro zofunika kwambiri, ndi dokotala kudziwa momwe warfarin idzasinthidwe komanso ngati zifaniziro zake ndizovomerezeka.