Thupi la munthu ndilopadera, lovuta kwambiri. Ngakhale mbiri yakale ya zamankhwala, mpaka pano, zonse zomwe zilipo ndi mphamvu za thupi la munthu sizinaphunzire bwino. Mahomoni ndi imodzi mwa njira zamphamvu zodzipangira thupi, ndipo m'nkhani ino tikambirana za mmodzi wa iwo - androstenedione. Zowonjezereka, zowonjezera ndi androstenedione, momwe mungachepetse androstenedione, komanso ngati kuli koyenera kudandaula ngati mayeso a ma laboratory asonyeza kuti hormone androstenedione yakwera mwa inu.
Kodi Androstenedione ndi yani?
Androstenedione ndi hormone ya adrenals ndi gonads. Icho chimapangidwa mu thupi la amuna ndi akazi. Zili zosagwirizana kwambiri ndi chitukuko cha mahomoni ogonana amuna ndi akazi, makamaka estrogen ndi testosterone. Mavitamini ochulukawa m'magazi amalola chiwindi ndi mafuta kuti azipanga mahomoni ogonana.
Mlingo wa androstenedione umayamba kuwonjezeka kwambiri kuchokera zaka 7-8. Atapeza munthu wa zaka 30, kukula kwa homoni imeneyi kumayamba kuchepa.
Androstenedione: chizoloŵezi cha amai ndi abambo
Ndiyeso yachiwiri ya androstenedione m'magazi, malingana ndi msinkhu wa munthuyo:
- ana 1-7 masiku atabadwa - 20-290 ng / 100ml;
- Makanda (miyezi 1-12) - 6-68 ng / 100ml;
- ana a zaka 1-10 zaka - 8-50 ng / 100ml;
- Achinyamata (zaka 10-17) - 8-240 ng / 100ml;
- amuna - 75-205 ng / 100ml;
- amayi - 85-275 ng / 100ml.
Zolakwika zozindikirika kuchokera ku kachitidwe ka normally ka androstenedione zikhoza kuwonedwa ndi kudya kwa mankhwala osokoneza bongo, zotupa zamatenda osiyanasiyana komanso matenda osiyanasiyana.
Androstenedion kukwera: zimayambitsa
Zifukwa za androstenedione yowonjezereka zingakhale matenda mu adrenal ndi / kapena ovarian ntchito. Nthawi zambiri, kuwonjezeka kwa androstenedione kumasonyeza matenda amenewa:
- polycystic ovary;
- hyperplasia wa adrenal cortex;
- Matenda a Itenko-Cushing;
- akazi osteoporosis;
- stromal hypertecosis wa thumba losunga mazira;
- zofupa za m'mimba zosiyana siyana ndi matenda ena.
Mlingo wotsika wa androstenedione umapezeka pakakhala palibe mazira kapena adrenal cortex.
Malingana ndi nthawi ya tsiku, gawo la msambo, ndi androstendione mlingo ndi wosiyana. Mitengo yapamwamba imapezeka m'mawa, ndipo pakati pa kusamba kwa akazi. Pakati pa mimba, mlingo wa homoni iyi umachulukanso.
Androstenedione yakwera: zizindikiro
Ngati androstenedione mwa amayi akukwera, kaŵirikaŵiri pamakhala kutaya tsitsi kwambiri (hirsutism), matenda opatsirana. Kuwonjezeka kwa mlingo wa homoni imeneyi kungayambitsenso kutha msinkhu, umatine magazi, mitundu yosiyanasiyana ya zovuta zomwe zimachitika m'thupi lachiberekero motsutsana ndi msinkhu wa kusamvana kwa mahomoni ambiri.
Amakhulupirira kuti kuwonjezeka kwa androstenedione kumabweretsa kuwonjezeka kwa minofu, ndipo chifukwa chake ma hormone ndi mapulani omwe ali nawo ndi otchuka kwambiri pakati pa omanga thupi, ngakhale kuti alibe anabolic zotsatira. Pakalipano, kuvulazidwa kwa mankhwala osagwiritsidwe ntchito kwa mankhwalawa nthawi zina kumakhala ndi zotsatira zabwino zogwiritsira ntchito - maliseche, kukulitsa prostate, kuphwanya thupi (mwachitsanzo, kukula kwa abambo), tsitsi lowonjezera - liri kutali ndi zotsatira zake zonse kulandila kosayendetsedwa.
Androstenedione pamwamba: mankhwala
Ngati msinkhu wa androstenedione uli wokwera kwambiri kwa amayi, nthawi zambiri mankhwala amafunika. Kuti mudziwe ndi kulongosola mankhwala okwanira, muyenera kulankhulana ndi a endocrinologist ndi azimayi (kwa akazi) kapena androlog (kwa amuna).
Amagwiritsidwa ntchito kwambiri: dexamethasone, clomiphene, mitundu yambiri ya kulera. Chithandizo cha mankhwala, mndandanda wa mankhwala ndi njira zothandizira zimasiyanasiyana kwambiri malinga ndi zomwe zimayambitsa ndi chikhalidwe cha vuto, kukhalapo kwa matenda osokoneza bongo, msinkhu komanso mkhalidwe wa wodwalayo. Kudziletsa sikuletsedwa. Mankhwala onse a mahomoni ayenera kulembedwa ndi katswiri wodziwa bwino.