Kukonzekera kwa Bisphosphonate

Gulu lapadera la mankhwala omwe amateteza kupweteka kwa mafupa ndi chiwonongeko chake ndi osteoclasts amagwiritsidwa ntchito mwakhama pochiza matenda odwala matenda a m'mimba mwa akazi. Bisphosphonate kapena dysphosphonate kukonzekera ndi mapangidwe omwe ali ofanana kwambiri ndi pyrophosphates zachilengedwe zosagwirizana ndi resorption. Lero iwo amaonedwa kuti ndiwo mankhwala okha a matenda odwala matenda a mitsempha.

Mayina okonzekera gulu la bisphosphonate

Mtundu wa mankhwala womwe umaganiziridwawo umagawidwa m'magulu akulu awiri - mankhwala omwe ali ndi nayitrogeni ndi mankhwala popanda.

Mitundu yoyamba ikuphatikizapo:

1. Alendronic acid. Amalimbikitsa kwambiri kubwezeretsa kwa kapangidwe kake ndi kupanga mapangidwe ake olondola a mafupa, kuyendetsa kusinthanitsa ndi kusinthika. Kaŵirikaŵiri amaperekedwa kuti azikhala ochepa komanso odwala matenda opatsirana matenda a mitsempha, matenda oopsa a hypercalcemia ndi deforming osteitis, pofuna kuteteza fractures;
2. Zolendronate kapena zoledronic acid. Kuchotsa ntchito za mafupa a osteoclasts, koma sizimakhudza njira ya fupa la mineralization, makina ndi mawonekedwe apangidwe;
3. Clodronic acid (Clodron, Bonefos). Amachepetsa chiopsezo cha mafupa, amachititsa kuchepetsa thupi. Amagwiritsidwa ntchito pa mankhwala oyesera, posankha kuwononga macrophages;
4. Bondronate (ibadronic acid). Anapangidwira mwachindunji kuti azitha kulandira akazi, makamaka okhudzidwa ndi nthawi yapadera. Amagwiritsidwanso ntchito pa mankhwala opatsirana pogwiritsa ntchito mahomoni.

Bezazotistye bisphosphonates ingatengedwe ndi metastases mu mafupa, mitundu yoopsa ya zotupa zowopsya, hypercalcemia. Pankhaniyi, kusankha koyenera ndi mlingo woyenera, zomwe dokotala ayenera kuwerengera. Apo ayi, makamaka ndi overdose, mavuto angayambe.

Mndandanda wa bisphosphonate kukonzekera popanda nayitrogeni:

1. Tiludronate. Kuwonjezera kuchuluka kwa minofu ya mafupa, kotero nthawi zambiri imatchulidwa pamaso pa ziphuphu ndi zophulika;
2. Xidiphon, Pleistat kapena sodium etidronate. Amagwiritsidwa ntchito kwambiri mu mankhwala ovuta a matenda a Paget, matenda a chilengedwe, hypercalcemia, osteoporosis;
3. Ibironiyamu. Zimathandiza bwino ndi mankhwala otchedwa hormonal mankhwala ochizira mankhwala m'malo omwe amatha msambo;
4. Clodronate. Zimalepheretsa kuwonongeka kwa makina a calcium, kukula kwa matenda otupa thupi. Mankhwalawa amaperekedwa kwa zilonda zotupa zowononga, leukemias, lymphomas, metastases yambiri.

Malangizo a bisphosphonates

Kuloledwa kwa mankhwala omwe tawatchula pamwambawa akuchitika malinga ndi malangizi a dokotala 1 nthawi patsiku.

Bisphosphonates samasunthika bwino kwambiri, choncho amafunika kutsukidwa ndi madzi owiritsa bwino kwambiri kutentha kwabwino.

Ndikofunika kuwona kusiyana pakati pa kuvomereza zakudya ndi mankhwala a bisphosphonate. Mapiritsi ayenera kutengedwa maola 1.5 asanadye chakudya chopanda kanthu - palibe kale kuposa mphindi 60 mutatha kudya.

Chimodzi mwa zinthu zosasangalatsa za mankhwalawa ndizokhoza kukhumudwitsa mucosa wa mimba, kuti awononge mapangidwe ang'onoang'ono a zilonda pamwamba pake. Choncho, mutatha kumwa bisphosphonates simungathe kugona nthawi yomweyo, ndizofunikira kwa mphindi 90 (osachepera) kuti mukhale pamalo abwino, mukhoza kukhala, koma ndibwino kuyenda pamapazi kapena kugwira ntchito zapakhomo. Izi zidzateteza zotsatira zotere monga kupweteka kwa mtima , kutsitsimula kwa reflux ndi esophagitis.