ACE Inhibitors

Angiotensin-kutembenuza mavitamini amasintha mawonekedwe a angiotensin-ine mu angiotensin II. Ndipo zoterezi, monga momwe zimadziwira, spasmodically amachititsa kuti magazi aziponderezedwa mwa anthu. Izi zimachitika pochepetsa ziwiya, komanso kuponyera aldosterone. Pofuna kuteteza angiotensin, ACE inhibitors akhoza kulamulidwa.

Choncho, mankhwala a ACE inhibitor ndi anti-antiperpersive agents omwe akhala akuvomerezedwa bwino kwa zaka zoposa 30 pa kukwera kwa magazi. Kupititsa patsogolo zotsatira za inhibitor akulangizidwa kuti agwirizane ndi diuretic.

Chizindikiro cha ACE inhibitors

Posiyanitsa mankhwala, zigawo zosiyana zimagwiritsidwa ntchito. Choncho, malinga ndi nthawi ya zotsatira, magulu oterewa amasiyana kwambiri:

1. Kutengeka kwa nthawi yochepa. Mphamvu za ndalamazi zimakhala pafupifupi maola asanu ndi awiri ndi asanu ndi awiri. Ngati simutenga lipiritsi lotsatira panthawiyi, pangakhale kulumpha kwachangu kumapeto. Zimaphatikizapo, mwachitsanzo, Captopril , zomwe ziyenera kutengedwa katatu patsiku.
2. Amatanthawuza ndi chikoka chokhazikika. Zimathandiza maola 12. Lembani mankhwalawa kawiri pa tsiku - kawirikawiri m'mawa ndi madzulo. Mtsogoleri wamkulu wa mapiritsi-inhibitors a ACE - Enalapril .
3. Mankhwala amatenga nthawi yaitali. Ndalamazi zimavomerezedwa nthawi zonse kamodzi patsiku. Komabe, panthawi yovuta, kulandiridwa kwa nthawi ziwiri ndi kotheka. Gululi likuphatikizapo Ramipril , Lisinopril ndi ena. Mu gulu lomwelo la mankhwala kumeneko, zotsatira zake zimasungidwa mpaka maola 48 pambuyo pa mapiritsi omaliza.

Poganizira zochitika za pharmokinetic, magulu otsatirawa amasiyanitsa:

• mankhwala omwe chimakhala chogwiritsidwa ntchito;
• mankhwala opatsirana.

Komanso, ACE inhibitors za mbadwo watsopanowo amagawidwa malinga ndi njira yakutsata yotsatira:

• kuchotsedwa ndi impso (za dongosolo la 70%);
• kupyolera mwa njira yamakono ndi cholagogic;
• Kuchetsedwa ndi bile kupyolera m'mimba.

Kusiyanitsa kwa mankhwalawa n'kosavuta chifukwa dokotala akhoza kupereka ndondomeko yoyenera kwa wodwala ameneyu kuchokera mndandandanda wa zipangizo zachipatala. Ubwino wonse wa kukonzekera ndi zenizeni za zotsatira zake pa zamoyo zimaganiziridwa pano.

Zotsatira Zotsatira za ACE Zizindikiro

Ngakhale yabwino ACE inhibitor imapereka zotsatira zosiyanasiyana:

• chifuwa chachikulu, chotsutsana ndi kusungunula kwa bradykinin mu dongosolo la kupuma;
• hypotension ;
• kufooka kwakukulu;
• kukoma kokha pakamwa;
• kukwera mu creatinine;
• Hyperkalemia, mlingo umene umakhala wovomerezeka mwa kutenga mankhwala ophera tizilombo;
• zovuta;
• kuwonjezereka kwa matenda ozungulirana, ndi zina zotero.

Maonekedwe a chimodzi mwa zotsatirazi ndi chifukwa choti mwamsanga mukumane ndi dokotala kukatenga mankhwala ena. Ngati mumanyalanyaza ma alarm kapena yesetsani kusankha mankhwala enieni, mungangowonjezera vutoli.

Zotsutsana ndi kudya kwa ACE inhibitors

Pali zifukwa zingapo zomwe ntchito ya ACE inhibitors imaletsedweratu. Izi zikuphatikizapo:

• mimba;
• zofooka za mtima;
• stenosis ya mitsempha yopita ku impso;
• chithandizo;
• nyamakazi;
• nthawi yachipatala;
• hypotension;
• kusagwirizana ndi zina zotero.

Pazifukwa zonsezi, kuyang'anira kwa mankhwala a ACE inhibitor kumakhala koyenera ngati mankhwala ena ali osagwira ntchito. Pachifukwa ichi, dokotala atatha kufufuza bwinobwino wodwalayo ayenera kulemedwa pa zoopsa zomwe zingakhalepo komanso phindu lenileni.