Prokinetics ndi mankhwala omwe ali m'magulu a m'mimba omwe amachititsa kuti zikhale zovuta. Chochititsa chidwi chikugwirizana nawo. Mndandanda wa mankhwala osokoneza bongo, omwe angazindikiridwe ndi onse gastroenterologists, salipo. Akatswiri osiyanasiyana amalembetsa mndandanda wa mndandanda womwewo. Kodi prokinetics ndi chiyani?
Otsutsa amatsenga a dopamine receptors
Zotsatira za otsutsa a prokine zimadalira kuti amamangirira mwamsanga ku D2-dopamine receptors ndipo amachepetsa kwambiri yankho lawo ku zizindikiro zachilengedwe za thupi la munthu. Chifukwa cha izi amathandiza kuti ntchito yamagalimoto ikhale yogwira ntchito, komanso kuyambitsa zotsutsa. Mndandanda wa mankhwala oterewa ndi awa:
- Bromopride;
- Chiwonongeko;
- Metoclopramide;
- Dimetramipid.
Kaŵirikaŵiri, zonsezi zimagwiritsidwa ntchito pochiza matenda a m'mimba Domperidone, mosasamala kanthu kuti ndizovomerezeka m'badwo wachiwiri. Izi zili choncho chifukwa chakuti alibe zotsatira zoyipa.
Akatswiri ena amatchula gulu la otsutsana ndi Itopride. Koma movomerezeka izi sizikudziwika, chifukwa zimakhala ndi zotsatira zolepheretsa acetylcholine. Komanso m'gulu lino la prokinetics akukonzekera za Reglan ndi Cerukal. Ndipo zonse chifukwa cha chogwiritsira ntchito chawo ndi metoclopramide. Nthawi zina, zimayambitsa tachycardia, tinnitus, kugona ndi chizungulire.
Otsutsa amatsenga amagwiritsidwa ntchito pamene:
- achalasia wa supopu ;
- chilonda cha mmimba kapena duodenum;
- kudula kwa matumbo, komwe kumachitika pambuyo pa ntchito;
- kukondwa;
- chithandizo cha matenda a reflux a gastroesophageal;
- ntchito;
- chidziwitso choopsa cha ma ducts.
Nthawi zambiri, mankhwala osokoneza bongo omwe ali m'gululi akhoza kulamulidwa chifukwa cha matenda a impso ndi chiwindi, kusanza ndi kunyozedwa chifukwa cha matenda opatsirana, kapena mankhwala opatsirana. Amagwiritsidwa ntchito popewera kusanza pamaso pa mapoposcopy kapena maphunziro osiyanasiyana.
Prokinetics-stimulants ya m'mimba peristalsis
Prokinetics odziwika kwambiri a gulu ili ndi zokonzekera ndi mayina a Coordax ndi Mozapride. Zili zofanana kwambiri ndi njira yogwirira ntchito. Zimasiyana kokha mu Mozapride amene alibe mphamvu pa ntchito ya potassium, ndipo izi zimachepetsa kuopsa kwa kusokonezeka kwa mtima.
Gululi likuphatikizanso mankhwala monga:
- Aceclidine;
- Chidutswa;
- Physiostigmine;
- Pyridostigmine bromide;
- Galantamine;
- Neostigmine monosulfate.
Ma prokinetics-agonist a mapepala obwera
Mankhwala osokoneza bongo amakhalanso ndi mankhwala omwe amamatira m'matope (hormone yomwe imathandizira kuwonjezereka m'magulu otsika otchedwa sophgeal sphincter, omwe amachititsa kupezeka). Izi zikuphatikizapo:
- Azithromycin;
- Clarithromycin;
- Atilmotine;
- Erythromycin.
Mankhwalawa amachititsa kuti zikhale zolimba kwambiri. Zotsatira zake, mimba imachokera ku madzi kapena chakudya cholimba. Komanso, nthawi ya zomwe zili m'matumbo akulu amachepa kwambiri, ngakhale m'matenda ena, mwachitsanzo, ndi matenda a shuga gastroparesis kapena apang'onopang'ono dongosolo la scleroderma.
Ngati mwatchulidwa kuti abonist a agonist amatha kulandira, samalani chifukwa ali ndi zotsatira. Mwachitsanzo, Erythromycin, yotengedwa kwa nthawi yoposa mwezi, ikhoza kuonjezera chiopsezo cha imfa chifukwa cha kupweteka kwakukulu kwa mtima.