Hypothiazide ndi mankhwala omwe ali m'gulu la thiazide diuretics . Mankhwala amaperekedwa mwa mawonekedwe a mapiritsi. Kuwonjezera apo tidzakambirana, kuchokera kumagwiritsidwe ntchito ka Hypothiazide m'mapiritsi amasankhidwa kapena osankhidwa, zomwe zimatsutsana ndi zikhalidwe zawo.
Mapangidwe ndi mankhwala a Hypothiazide
Chophatikiza chachikulu cha Hypothiazide ndi hydrochlorothiazide. Monga zinthu zothandizira pa mapangidwe amapiritsi akuphatikizapo zowonjezera izi:
- talc;
- gelatin;
- magnesium stearate;
- chomera;
- lactose monohydrate.
Hypothiazide ndi diuretic yomwe, kuwonjezeranso, imakhala ndi mphamvu yowonongeka pamagulu a kuthamanga kwa magazi. Mfundo yothandizira mapiritsi imakhudzana ndi kulepheretsa mphamvu ya hydrochlorothiazide pa ntchito ya epithelium ya tubal renal. Izi zimawonetseredwa, makamaka, kuchepetsa kuyamwa kwa sodium, chlorine (komanso potaziyamu ndi mabicarbonates) komanso mlingo woyenera wa madzi. Palinso kuchepetsa kupitirira kwa uric acid ndi calcium ions ndi kuwonjezeka kwa excretion ya magnesium ions. Mankhwala a Hypothiazide ali ndi zotsatira zosiyanasiyana zosafunika za thupi lokhazikika mu asidi - zonse ndi acidification (acidosis) ndi alkalization (alkalosis).
Mwa kuchepetsa kuchuluka kwa madzi a extracellular omwe amapindula mwa kuchotsa sodium, chlorini ndi madzi a ions, komanso kukulitsa mitsempha yaing'onoting'ono, zomwe zimachitika mwakuya zikuwonetsedwa. Pachifukwa ichi, mankhwalawa alibe mphamvu pazidziwitso za magazi ndipo sizimayambitsa vutoli. Ntchito yodabwitsa ya Hypothiazide imakula ndi zakudya zopanda mchere. Komanso mankhwalawa amathandiza kuchepetsa kupanikizika kwa m'mimba.
Pogwiritsa ntchito mankhwalawa nthawi zambiri, mankhwalawa amathandiza kuchepetsa impso ya calcium ndi impso, zomwe zingathandize kwambiri pamaso a impso okhala ndi salsium salt.
Zisonyezo ndi zosiyana zogwiritsira ntchito Hypothiazide
Ma mapiritsi a Hypothiazid amalembedwa kuti azifupa komanso kuthamanga kwa magazi. Malingana ndi malangizo, mndandanda wonse wa zizindikiro za mankhwala awa ndi izi:
1. Zomwe zimapangitsa kuti magazi azigwiritsidwa ntchito mopitirira muyeso I komanso yachiwiri (monga njira ya monotherapy kapena kuphatikizapo njira zina zowonongeka).
2. Edema wa chiyambi chosiyana, chokhudzana ndi:
- matenda a nephrotic;
- matenda osagwira mtima;
- matenda osokoneza bongo;
- chiwindi cha chiwindi;
- glomerulonephritis;
- phwando la njira yamadzimadzi, etc.
3. Kufunika koteteza kuwonjezeka kwa mkodzo (makamaka mu nephrogenic shuga insipidus).
4. Kufunika koteteza mapangidwe amwala mu tsamba la mkodzo.
5. Glaucoma (mu mankhwala ovuta).
Zotsutsana ndi kutenga Hypothiazide:
- anuria;
- chotupa chachikulu kapena chosowa chodziletsa;
- matenda a shuga amakhala mu mawonekedwe aakulu;
- kusakwanira;
- mimba (ine trimester);
- malingaliro hypokalemia, hyponatremia, hypercalcemia;
- hypersensitivity kwa zigawo zikuluzikulu za mankhwala.
Mlingo wa Hypothiazide
Mlingo wa mankhwalawa wasankhidwa malingana ndi mawonekedwe a matenda ndi chikhalidwe chake. Mapiritsi ayenera kutengedwa pambuyo chakudya.
Kawirikawiri, mankhwalawa amatengedwa ndi 25-50 mg pa tsiku. Mlingo wa mankhwala wodwalayo umakhala 25-100 mg, ndi Hypothiazide yomwe imatengedwa kamodzi pa tsiku kapena tsiku lina lililonse. Pankhani yaikulu ya edema, mlingo woyamba wa mankhwalawo ukhoza kuwonjezeka kufika 200 mg patsiku. Mu machitidwe oyambirira, monga lamulo, tenga mapiritsi 25 mg tsiku lililonse.