Maantibayotiki a fluoroquinolones

Fluoroquinolones ndi mankhwala osokoneza bongo omwe mankhwala amapangidwa mwaluso. Chiyambi cha kulowa m'moyo wathu, monga mawonekedwe a mankhwala a mankhwalawa (ofloxacin, ciprofloxacin), amawerengedwa kuti ndi zaka 80 za m'ma XX. Mbali yawo yosiyana ndi yosiyana kwambiri ndi momwe zimakhalira kumenyana ndi tizilombo toyambitsa matenda, tizilombo toyambitsa matenda, komanso kuchuluka kwa kumwa mankhwala mu maselo a thupi, ndikufalitsa kuti tizilombo toyambitsa matenda.

Zaka khumi, dziko lapansi linawona mibadwo ya fluoroquinolones III ndi IV, yomwe inali yowonjezeka kwambiri pomenyana ndi mabakiteriya (makamaka pneumococci), tizilombo toyambitsa matenda, tizilombo toyambitsa matenda tizilombo toyambitsa matenda. Chimodzi mwa ubwino wa m'badwo wotsiriza fluoroquinolones ndi momwe zimakhudzira kwambiri zinthu.

Mankhwala opha tizilombo a gulu la fluoroquinolones, omwe amalowa m'thupi mwathunthu, amachititsa kuti ntchito ya DNA-gyrase ikhale yovuta kwambiri, yomwe imapha tizilombo toyambitsa matenda.

Kugwirizana kwa fluoroquinolones

Fluoroquinolones ali ndi zizindikiro zambiri zogwiritsira ntchito pazochipatala. Ndi chithandizo chawo, zimalimbikitsidwa kuchita njira zothandizira zothandizira matenda oopsa, zimakhala zogwirizana ndi mankhwala ena opatsirana pogonana.

Fluoroquinolones classification

• yoyamba - yopanda fluorinated finolones;
• yachiwiri-gram-negative fluoroquinolones;
• wachitatu - kupuma fluoroquinolones;
• wachinayi - kupuma komanso kuphwanya antianaerobic fluoroquinolones.

Mafluoroquinolones a m'badwo watsopano amagwiritsa ntchito:

• Matenda a matenda opatsirana ndi matenda osiyanasiyana a ENT: bronchitis, chibayo, pachimake sinusitis, sinusitis (komanso mavuto omwe amabwera chifukwa cha matenda a mitundu mitundu);
• Matenda opatsirana a impso, komanso njira yobadwa nayo: cystitis (yovuta komanso yosachiritsika), pyelonephritis (ovuta, aakulu, ndi mavuto omwe amabwera chifukwa cha matendawa);
• ndi matenda opatsirana m'mimba: kamwazi, salmonellosis, matenda opatsirana m'mimba, typhoid fever;
• chifukwa cha matenda a khungu ndi dongosolo;
• ndi matenda omwe amafalitsidwa pogonana: gonorrhea, soft chancroid;
• Kuchiza ndi kupewa matenda osiyanasiyana opatsirana, kutetezeka kwa chitetezo chokwanira kapena kuphwanya ntchito zake;
• kuti thupi libwezeretsedwe mu nthawi ya postoperative.

Maantibayotiki a zotsatira za magulu a fluoroquinolones:

• chifukwa cha hematopoietic system: kuchepa kwa magazi, kuchepa kwa leukocyte m'magazi (zomwe zimapangitsa kuchepa kwa chitetezo cha thupi) ndi mapulatelets (omwe amawononga magazi coagulability);
• chifukwa cha m'mimba: kupweteka m'mimba, kukhumudwitsa, kuchepetsa chilakolako, kuoneka kwa mseru, kukoma kwachitsulo m'kamwa, nthawi zambiri - kutupa kwa matumbo;
• kwa chiwindi: kuwonongeka kwa mphamvu yake yogwira ntchito;
• chifukwa chachikulu cha mitsempha: migraine, kusowa tulo, nkhawa, nkhawa, kuwonongeka kosaoneka, nthawi zambiri - kutaya, kupezeka ndi kukhumudwa;
• pa khungu: kuoneka ngati kuthamanga thupi, kuwonekera kuyabwa;
• chifukwa cha urinary system: nephritis, kusintha kwa mtundu wa mkodzo;
• chifukwa cha ntchito zamatomu: feteleza augmentation mwa amuna;
• chifukwa cha fupa ndi minofu: ululu.