Chotupa cha tumor necrosis chimatchedwa mapuloteni ochulukirapo ochulukirapo, opangidwa ndi maselo osadziwika bwino (macrophages, eosinophils). Pochita maselo ena a thupi, mapuloteniwa amachititsa zotsatira zotsatirazi:
- kuthamanga kwa mankhwala ofunikira;
- kusintha muzowona za makoma a mitsempha;
- Kuwonjezeka kwa ma interleukin (1, 6, 8);
- chitetezo ku tizilombo toyambitsa matenda;
- lamulo la kupanga mankhwala;
- zotsutsana.
Mayeso a magazi chifukwa cha chifuwa cha necrosis
Popeza chotupa cha necrosis chimachita mbali iliyonse ya thupi, thupi lake limadalira mphamvu ya kutupa. Ngati kuyezetsa magazi kumasonyeza kuti chotupa cha nthenda yotchedwa necrosis chikukwera, ndiye izi zikhoza kusonyeza kupweteka kotereku:
- matenda aakulu opatsirana (chiwindi cha C, matenda a herpes, endocarditis, etc.);
- sepsis ;
- chikhalidwe chowopsya;
- chithandizo;
- psoriasis;
- matenda;
- kukana ziwalo zowikidwa;
- matenda a atherosclerosis a mitsempha ya mtima ndi ubongo;
- chonchi;
- matenda ;
- matenda opatsirana, ndi zina zotero.
Nthenda yotchedwa necrosis ya chotupa mumatope a oncology
Kuzindikira kuchuluka kwa chifuwa cha necrosis ndi kofunikira poyang'anira njira ya khansa. Ponena za maselo amtunduwu, mapuloteniwa amasonyeza ntchito, yomwe imasonyezedwa mu hemorrhagic necrosis ya maselo osawononga maselo osawononga maselo popanda kuwononga maselo wathanzi. Malingana ndi chinthu chotupa cha necrosis chokhazikitsidwa mwachindunji kuchokera kwa magazi opereka, mankhwala osokoneza bongo amatha kupangidwa, pamene amakhala ndi poizoni ochepa thupi. Mwachitsanzo, mothandizidwa ndi mankhwalawa.