M'maganizo amakono ndi mankhwala apamwamba, zowonjezera zina zimachitika nthawi zonse. Chilichonse chimapangidwa kuti chikhale chosavuta kuchiza matenda ena. Chimodzi mwa zinthu zowonjezereka zopezeka ndi ma antibodies monoclonal. Ma antibodies ambiri omwe amapangidwa ndi thupi ndi polyclonal. Mwachidule, iwo apangidwa kuti amenyane ndi antigens osiyanasiyana, zomwe zimachepetsetsa kwambiri chithandizo cha mankhwala. Mankhwala a monoclonal amachita mwachindunji, kulola kuti alandire zotsatira zabwino kwambiri.
Mfundo yothandizira ndi ma antibodies monoclonal
Pakalipano, ma antibodies amodzi amagwiritsidwa ntchito pa chithandizo kapena chomwe chimatchedwa chithandizo chowongolera. Monga momwe mayesero amasonyezera, njirayi imasonyeza zotsatira zabwino za chithandizo.
Mankhwala a monoclonal ndi ma antibodies omwe amachokera ku chipangizo chimodzi. Izi zikutanthauza kuti onse ali ndi chiwerengero chimodzi choyambirira. Mankhwala a monoclonal amagwiritsidwa ntchito:
- colitis ;
- nyamakazi ya nyamakazi;
- psoriasis;
- multiple sclerosis .
Amathandizira kulimbana ngakhale mitundu yovuta kwambiri ya oncology.
Mfundo yogwiritsira ntchito ma antibodies monoclonal ndi yophweka: amazindikira ma antigen ena ndipo amawagwiritsira ntchito. Chifukwa cha izi, chitetezo cha mthupi mwamsanga chikuzindikira vutoli ndipo limayamba kulimbana nalo. Ndipotu, ma antibodies monoclonal amalola thupi kuti lichotse ma antigen. Chinthu chinanso chachikulu cha MCA ndi chakuti zimakhudza maselo osinthika osasokoneza thupi popanda kuvulaza thanzi.
Mankhwala a monoclonal mu oncology
Kwa odwala ambiri omwe ali ndi matenda a oncology, mankhwala osokoneza bongo omwe amaphatikizana ndi ma antibodies monoclonal akhala chiyembekezo chokha chobwezeretsa. Mbali yaikulu ya odwala okhala ndi ziwalo zazikulu zoopsa ndi zowonongeka pambuyo poti mankhwalawa adamva bwino.
Ubwino wa ICA ndiwonekeratu:
- Kuphatikizidwa ndi maselo a khansa, ma antibodies monoclonal samawonekera kwambiri, koma amachepetsanso. Ndipo ndi maselo osasinthika omwe amasinthidwa, thupi limakhala losavuta kulimbana.
- Mankhwala a monoclonal omwe apeza cholinga chawo amathandiza kuti zisawonongeke za kukula kwa zotupa. Chifukwa cha chithandizo ichi cha oncology ndi chosavuta kwambiri.
- Ma antibodies amapezeka mu labotale, komwe amagwirizanitsidwa ndi magulu ochepa a radioactive. Kudutsa ma particles kupyolera mu thupi, MCA imapereka iwo ndendende ku chotupa, kumene iwo amachita.
Chithandizo cha khansa ndi ma antibodies angafanane ndi radiotherapy. Koma mosiyana ndi omaliza, ICA ikuchita zinthu zovuta. Cholinga chawo chimapangitsa kuti tizigwiritsa ntchito tizilombo toyambitsa matenda.
Mankhwala osokoneza bongo omwe ali ndi ma antibodies monoclonal
Ngakhale kuti ICA inakhazikitsidwa osati kale kwambiri, makonzedwe omwe ali nawowa amawoneka okongola kwambiri. Mankhwala atsopano amawonekera nthawi zonse.
Ma antibodies ambiri odziwika kwambiri omwe amagwiritsidwa ntchito masiku ano pofuna psoriasis, multiple sclerosis, khansa, nyamakazi ya nyamakazi, kutupa kwa chilonda kumawoneka ngati:
- Alemtuzumab;
- Alefacept;
- Daclusimab;
- Okrelizumab;
- Ustenkinumab;
- Soliximab;
- Ofatumab;
- Epratuzumab;
- Clenoliximab;
- Bevacizumab;
- Trastuzumab;
- Adalimumab;
- Enbrel;
- Infliximab ndi ena.
Inde, ma antibodies monoclonal, monga mankhwala ena ambiri, akhoza kukhala ndi zotsatirapo. Kawirikawiri, odwala atagwiritsa ntchito ICA amadandaula za kuwonetseratu kwachinyengo: kuyabwa, kuthamanga. Nthawi zambiri, chithandizo chimaphatikizapo kunyoza, kusanza, kapena matenda a m'mimba.