Kodi munayamba mwaganizapo chifukwa chake mankhwala osokoneza bongo ali ndi ndalama zosiyana? Imodium yotchuka ndi yokwera mtengo kuposa Loperamide, ndipo pambuyo pa mankhwala onsewa ali ofanana, ali ndi chinthu chimodzi chogwira ntchito. Zizindikiro za ntchito ya Loperamide zidzakhala zofanana, ndipo mtengo wake udzakudabwitseni. Kodi nsomba ndi ziti?
Mbali za Loperamide Hydrolochromide
Pogwiritsa ntchito Imodium ndi Loperamide, chimodzi chokha ndi Loperamide hydrochloride, zomwe zimagwiritsidwa ntchito ndizo:
- kutsegula m'mimba ;
- kutsegula m'mimba;
- normalization ya m'mimba motility pambuyo opaleshoni ntchito.
Zizindikiro zotere za Loperamide zimachokera ku chidziwitso chakuti mankhwalawa ali ndi vuto lopweteka pa minofu yosalala ya m'matumbo ndipo chifukwa cha ichi kusungirako ziweto kumachitika. Loperamide amatanthauza kukonzekera opioid ndipo amachokera ku piperidine. Zimalepheretsa zomwe zimapezeka m'matumbo zomwe zimakhudzidwa ndi opiates ndipo zimayambitsa sphincter kuti igwirizane, ndipo imoto imagwira ntchito. Poyamba, mankhwalawa amagwiritsidwa ntchito pochizira gastroenteritis ndi mitundu yosiyanasiyana ya kutupa kwa matumbo, masiku ano amagwiritsidwa ntchito makamaka pofuna kuthana ndi kutsekula m'mimba.
Loperamide anapezedwa ndi asayansi a ku Belgium mu 1969 ndipo kuyambira pamenepo wakhala akulimbikitsidwa kwambiri pamsika wotchedwa Imodium. Mofananamo, m'mayiko ambiri, kufanana kwa mankhwala omwe ali ndi zizindikiro zofanana kunatulutsidwa. Pakhomo la Loperamida-Akri zonsezi zikuwonetseratu ntchito. Komabe ena mwa mankhwalawa ndi osiyana, monga - kuchuluka kwa kuyeretsa kwa mankhwala, mphamvu ya kupanga ndikupezeka kwa maphunziro atsopano pa mankhwala. Izi ndi zomveka, chifukwa kupanga zambiri, ndalama zambiri zomwe zingapereke mafunso amenewa.
Mwachitsanzo, m'zaka za m'ma 1990, Johnson ndi Johnson, omwe tsopano anali kulimbikitsa Imodium, adachotsa mankhwalawa pamsika chifukwa cha imfa zambiri ku Pakistan. Kenaka pogwiritsa ntchito Imodium, ana 19 anavutika. Maphunziro osamala a loperamide pa izi sanathe ndipo mankhwalawa adakonzedwanso. Zoona zake n'zakuti ana, makamaka, makanda, piperidine ndi zotsatira zake zimayambitsa kupweteka kwa matumbo mpaka kuimfa. Monga lamulo, zotsatira zoterozo zimawonedwa kwa ana osapitirira zaka ziwiri, pokalamba zoterezi sizichitika. Ndipo, komabe, kugwiritsa ntchito mankhwala osokoneza bongo, kuphatikizapo loperamide, m'mayiko ambiri amaloledwa kwa ana oposa zaka zisanu ndi chimodzi, komanso ku Australia, ana a zaka zoposa 12.
Mlingo ndi kayendedwe ka Loperamide
Pofuna kulandira kutsegula m'mimba, akuluakulu amapatsidwa mlingo woyamba wa Loperamide mu 4 mg, womwe umagwirizana ndi 2 capsules a mankhwala. M'tsogolomu, tengani mankhwala a 2 mg pambuyo pa chitsime chilichonse, ngati akupitiriza kukhala wofatsa, madzi. Zikakhala kuti sitoloyo ndi yachilendo, kapena wodwalayo ali ndi chitetezo , kugwiritsa ntchito mapiritsi a Loperamide ayenera kuchotsedwa.
Pofuna kuchiza matenda otsekula m'mimba, akuluakulu amalamulidwa 2 mg wa mankhwala 1-2 pa tsiku mpaka mkhalidwewo ukukhazikika.
Ana oposa zaka zisanu ndi chimodzi amasankhidwa payekha ndipo amachokera kulemera kwa thupi la mwanayo. Thandizo
Mlingo waukulu wa tsiku la Loperamide kwa akulu ndi 16 mg, kwa ana 6-8 mg.
Pochiza chithandizo chotchedwa "kutsekula m'mimba", kutsegula m'mimba ndi mantha, mankhwalawa amaperekedwa mogwirizana ndi dongosolo lomwe likufanana ndi mankhwala opatsirana m'mimba.
Mosamala, Loperamide imaperekedwa chifukwa cha kuphwanya chiwindi ndi impso. Mankhwalawa akutsutsana:
- mimba;
- amayi oyamwitsa;
- ana mpaka zaka zisanu ndi chimodzi.